HWA A. LIM's (HAL's) PAGE : Bioinformatics
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Binformatics; bioinformatics -
Information content and information flow in
Biotechnology, information technology, and nanotechnology

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HAL Bioinformatics & Binformatics

HAL's Curriculum Vitae in (WORD ) (pdf )
HAL Meets the Press
HAL Cited in...
HAL Lectures
HAL Writes Papers Dr. Hwa A. Lim - Bioinformatics HAL Writes Books
HAL chairing an international meeting.
HAL Affiliations
HAL Students...
HAL Says

Dr. Hwa A. Lim (HAL) has been CEO of MIRAHI, Inc.; Founding member of D'Trends, Inc. [merged] (see Bernstein Report) - a professional company servicing the biotechnology, pharmaceutical and healthcare sectors; Chairman of the Board of GeneGo, Inc. [acquired] - a systems biology company for drug discovery, with flagship product MetaCoreTM. He was a keynote speaker at a Fortune 500 Summit to lecture on "From Biodata to Bigdata" (2016); a panelist of "Beyond Bioinformatics: Moving from information to knowledge" at Bio'98 (BIO); a BioMass panelist organized by the American Association Advancement of Science (AAAS) at Stanford University (1996).

In the academic sector, Dr. Lim is Adjunct Professor of Molecular and Cell Biology, and the Mathematical Sciences, University of Texas at Dallas (UTDallas); Visiting Professor of Institute of Genetics (Beijing), and Visiting Professor of Peking University (Beijing), and Visiting Professor of Sun Yat-sen University (Guangzhou). Between October 1987 and November 1995, Dr. Lim was a tenured faculty member and program director at the Supercomputer Computations Research Institute (SCRI) at Florida State University (FSU).

In the private sector, Dr. Lim has worked as consultant/advisor for McKinsey, Prudential, VAXA, Eli Lilly and Company, Monsanto and Company, Dupont CR&D, Robertson Stephens (Ref), U.S. government, Taipei government, Chinese government, Malaysian government, institutions in China, India and other organizations. He was appointed a member of the International Expert Panel, BioValley, by the Ministry of Science, Technology and Environment, Malaysia (2004).

Within the United Nations (UN), Dr. Lim has two affiliations: (1) a Bioinformatics Expert for the Food and Agricultural Organization (FAO), United Nations (1993) [UN No. UNDP-ROK095], and (2) a member of UNESCO (United Nation's Educational, Scientific, and Cultural Organization) CID [UNESCO Cid No. 17961].

At the federal level of the US government, Dr. Lim was on the review panels of the US National Science Foundation (US NSF), US National Cancer Institute (US NCI).

Prior to the D'Trends venture, Dr. Lim was Vice President of Science & Technology at Pangea Systems, Inc., (later DoubleTwist - then a bioinformatics industry leader) and as Director of Bioinformatics [Ref. 1] at Hyseq Inc. (ticker symbol: HYSQ; now merged with Nuvelo, Inc., ticker symbol: NUVO; see Hyseq's blurb).

Started with short stints at the Strong Memorial Hospital, New York, and later computational work using computers at the John von Neumann Center at Princeton University, Dr. Lim launched his career. One of the milestones in his accomplished career is when he coined the neologism "bioinformatics" in 1986, initiated in 1990 and chaired the first 10 of the International Conference series "Bioinformatics & Genome Research", which was later acquired by Cambridge Healthtech. The Conference series helps set the direction of instrumentation improvement, biodata accumulation (thus big data) and genome research, leading to the current state of genome sequencing.

Dr. Lim is credited with establishing and shaping the field of bioinformatics, credits that earn him the title of "Father of Bioinformatics."

Dr. Lim is well-published, with over 150 papers in peer-reviewed journals and publications, and more than a dozen books in English.

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HAL Meeting the Press

Only those we can obtain or have obtained reproduction permission

" Dancing with Robots", "People in Science & Technology", The Star, June 12, 2017, (In English)
Permission: Digital copy acquired from Newspaper Direct, Inc., Vancouver, Canada.

" Nanotechnology - the next revolution", Business Times, August 6, 2005, (In English)
" Conference Seeks Biotech Business", Arab News, May 12, 2004.
[] " Proud Pioneer of Bioinformatics", The Star, June 15, 2003, (In ENGLISH)
[] "Applying Breakthroughs in Your Specialty Area", sina.com version, June 2003
OR Bio Era, No. 20, 2003.06, Bio-Era Bio-Club version, June 2003
OR Local copy version (In Chinese)
[] " How to climb the biotech bandwagon", New Sunday Times, October 13, 2002, (In ENGLISH)
[] " Negara berada di landasan betul majukan bioteknoloji", Utusan Malaysia, October 4, 2002, (In Malaysian Language)

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HAL Cited in...

Only those we can obtain or have obtained reproduction permission

" The salaryman's armor against swine flu", by M. Amedeo Tumolillo, and Robert Mackey, New York Times, October 7, 2009, (In English)
" The Global Technology Revolution: Bio/Nano/Materials trends and their synergies with information technology by 2015", by Philip S. Anton, Richard Silberglitt, and James Schneider, National Intelligence Council, National Defense Research Institue, 2001, (In English)
[] HAL on Albany Science Library
[] HAL cited in Newspaper, 12/28/2000, Computer Giants Invest in Genomics - "Big name computer and technology companies are staking their claim in the emerging world of 'bioinformatics' "
Local copy, James Heckman, LocalBusiness.com, Dec 28, 2000.

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Recent Lectures by HAL

Keynote Lecture at the Bay Area Chamber of Commerce, "Nanotechnology: Development, business and prospects", September 6, 2005, Santa Clara Marriott Hotel, Santa Clara, California, USA.
Keynote Lecture, Association of the Chinese Chamber of Commerce in Malaysia, "Nanotechnology: Business development and opportunities", August 4, 2005, Menara Promet, Kuala Lumpur, Malaysia.
Plenary Lecture. "Informatics, Bioinformatics, and Bininformatics", International Meeting on Frontiers of Physics, the Year of Physics to celebrate the centennial of the "miraculous year" when a young patent clerk Albert Einstein in Bern, Switzerland, revolutionized physics with five papers on relativity, quantum mechanics and thermodynamics, The Mines, Kuala Lumpur, Malaysia.
Workshop Coordinator and Speaker, "Make Your Creative Juices Flow", Universiti Technologi Malaysia, October 30, 2004, Skudai, Johore, Malaysia.
Distinguished Speaker, "Binformatics - informatic of biotechnology, information technology, and nanotechnology", Saudi Bio2004 International Conference, May 10-12, 2004, Jeddah, Saudi Arabia.
Keynote Lecture, "Nanotechnology in diagnostics and drug delivery", Current Trends in Drug Discovery Research, February 17-20, 2004, Lucknow, India.


"Big, Open Biodata in Health and Wealth", Linking the Belt and Road with Smart Biotech, July 6-7, 2018.
"Big, Open Q&A in Health and Wealth", Linking the Belt and Road with Smart Biotech, July 6-7, 2018.
"Biodata Behind Big, Open Data", The 7th International Conference of Veterinary Research, December 5-8, 2017.
"From biodata to bigdata", Fortune 500 Multinationals Lecture, September 29, 2016.
"Revival of the Fittest", IET Lecture, February 18, 2012.
"Creativity 2.0", PELTAC Lecture, February 14, 2012.

For earlier lectures, see: Hal's Cv

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Selected Peer-Reviewed Articles by HAL

Hwa A. Lim, "Nanotechnology in diagnostics and drug delivery" by Hwa A. Lim, Medicinal Chemistry Research, 13(6-7), 2005, pp. 401-413. (Abstract); (Article in Word).
Hwa A. Lim, "Bioinformatics and Cheminformatics in the Drug Discovery Cycle", In: Lecture Notes in Computer Science, Bioinformatics, R. Hofestaedt, T. Lengauer, M. Loffler and D. Schomburg (eds.), (Springer, Heidelberg, 1997), pp. 30-43. (Abstract); (Article in Word).
Hwa A. Lim, "Electrophoresis of Topologically Nontrivial Macromolecules: Mathematical and Computational Studies", International Journal Modern Physics C, 7(2), (1996), pp. 217-271. (Abstract).

Victor B. Strelets and Hwa A. Lim, "Compression of Protein Sequence Databases", Bioinformatics, 11(5), 557-561, (1995). (Abstract), (Abstract on OUP).
Victor B. Strelets and Hwa A. Lim, "Ancient Splice Junction Shadows with Relation to Blocks in Protein Structure", BioSystems, 36, 37-41, (1995). (Abstract), (Abstract on PubMed).
V.B. Strelets, I.N. Shindyalov, Hwa A. Lim, "Analysis of Peptides from Known Proteins: Clusterization in Sequence Space", J. Mole. Evolution, 39(6), 625-630, (1994). (Abstract), (Abstract on PubMed).
V.B. Strelets, A.A. Ptitsyn, L. Milanesi, Hwa A. Lim, "Data Bank Homology Search Algorithm with Linear Computation Complexity", Bioinformatics, 10(3), 319-322, (1994). (Abstract), (Abstract on OUP).
I.N. Shindyalov, V.B. Streletc, N.A. Kolchanov, Hwa A. Lim, "A Method for Multiple Alignment and Its Application in Homolog Compilation", Protein Seq. Data Anal., 5(5), 219-225, (1993). (Abstract)
V.V. Solovyev, S.V. Korolev, Hwa A. Lim, "A New Approach for the Classification of Functional Regions of DNA Sequences Based on Fractal Representation", Intl J. Genomic Res., 1(1), 109-128, (1993) (Abstract)
V.V. Solovyev, S.K. Salikhova and Hwa A. Lim, "Spatial Structure Calculations of alpha-Helical Domains of Protein Molecules Using Quasispherical Primary Approximations", In: Biomedical Modelling and Simulation, Ed. J. Eisenfeld, D.S. Levine and M. Witten, pp. 201-211 (Elsevier Science Publishers B.V., North Holland, 1992). (Abstract)
Hwa A. Lim, V.V. Solovyev, "A New General Approach for Searching Functional Regions Using Fractal Representation of Nucleotide and Amino Acid Sequences ", In: Harnessing Biotechnology for the 21st Century, Ed. M.R. Ladisch and A. Bose, pp. 387-391 (American Chemical Society, Washington, D.C., 1992). (Abstract)
D.K. Kuznetsov, Hwa A. Lim, "VisiCoor-A Simple Program for Protein Visualization", J. Molecular Graphics, 10, 21-28, (1991). (Abstract) (Abstract on PubMed).
Hwa A. Lim, G.W. Slater, J. Noolandi, "A Model of the DNA Transient Orientation Overshoot during Gel Electrophoresis", J. Chem. Phys., 92, 709-721, (1990). (Abstract), (Abstract on PubMed).
J. Noolandi, G.W. Slater, Hwa A. Lim, J.L. Viovy, "Generalized Tube Model of Biased Reptation for Gel Electrophoresis of DNA", Science, 243, 1456-1458, (1989). (Abstract)

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Books by HAL

Hwa A. Lim, Hippocratically Yours: Diseases, wellness, and safety, (2010), Forthcoming.
Hwa A. Lim, Ecofriendlily Yours: Energy, biofuels, green and clean technology, (2010), Forthcoming.
Hwa A. Lim, Healthfully Yours: Diseases, diet, fountain of youth and longevity, (2009), In Print.
Hwa A. Lim, Multiplicity Yours: Cloning, stem cell research and regenerative medicine, (World Scientific Publishing, River Edge, New Jersey, 2006), 450 pages.
Hwa A. Lim, Sex Is So Good, Why Clone?, (Ivy International Publishing, Inc., Santa Clara, California, 2004), 300 pages.
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Hwa A. Lim, and Carmelita Chao, A Stroll Down the Genetic World (In Chinese), (EN Publishing, Inc., Santa Clara, California, 2003), 252 pages.
Kingstone Best-Seller; Academia Sinica highly recommended book; university reference text; eBookstore highly recommended book.
Hwa A. Lim, CHANGE: In business, corporate governance, education, scandals, technology and warfare, (EN Publishing, Inc., Santa Clara, California, 2003), 488 pages.
Hwa A. Lim - Genetically Yours: Bioinformatics Hwa A. Lim, Genetically Yours: Bioinforming, Biopharming and Biofarming, (World Scientific Publishing Co., Singapore, New Jersey, Hong Kong, London, Bangalore, Shanghai), 2002, 417 pages.

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Other Titles

Hwa A. Lim - Pathways of Bioinformatics Hwa A. Lim (ed.), Pathways of Bioinformatics: From data to diseases, Briefings in Bioinformatics, Vol 3(1), March 2002, (Henry Stewart Publishers, London), 109 pages.
Guoxiong Xue, Yongbiao Xue, Zhihong Xu, Roger Holmes, Graeme Hammond, and Hwa A. Lim (eds.), Gene Families: Studies of DNA, RNA, Enzymes and Proteins, (World Scientific Publishing Co., New Jersey, 2001), 305 pages. Book cover.
John L. VandeBerg, John R. McCarrey, and Hwa A. Lim (eds.), Genes, Gene Families, and Isozymes, The Journal of Experimental Zoology, Vol. 282, No. 1/2, (Wiley-Liss, New York, 1998), 283 pages. Preface.
Hwa A. Lim - Molecular Bioinformatics Ralf Hofest輐t, and Hwa A. Lim (Hrsg.), Molecular Bioinformatics- Sequence Analysis, (Shaker Verlag, Aachen, Germany, 1997), 60 pages. Preface or ics program.
Roger S. Holmes, and Hwa A. Lim (eds.), GENE FAMILIES: Structure, Function, Genetics and Evolution, (World Scientific Pub. Co., New Jersey, 1996), 220 pages. Preface.
Hwa A. Lim - Bioinformatics and Genome Research Hwa A. Lim , and Charles R. Cantor, (eds.), Bioinformatics and Genome Research, (World Scientific Pub. Co., New Jersey, 1995), 529 pages.
Nikolay A. Kolchanov, and Hwa A. Lim, Computer Analysis of Genetic Macromolecules: Structure, Function and Evolution, (World Scientific Pub. Co., New Jersey, 1994), 556 pages.
Clement L. Markert, John G. Scandalios, Hwa A. Lim and Oleg L. Serov (eds.), ISOZYMES: Organization and Roles in Evolution, Genetics and Physiology, (World Scientific Pub. Co., New Jersey, 1994), 309 pages.
Hwa A. Lim - Bioinformatics, Supercomputing and Complex Genome Analysis Hwa A. Lim , James W. Fickett, Charles R. Cantor, and Robert J. Robbins (eds.), Bioinformatics, Supercomputing and Complex Genome Analysis, (World Scientific Pub. Co., New Jersey, 1993), 648 pages.
Hwa A. Lim - Bioinformatics, Supercomputing and the Human Genome Charles R. Cantor, and Hwa A. Lim (eds.), Electrophoresis, Supercomputing and the Human Genome, ( World Scientific Pub. Co., New Jersey, 1991), 325 pages.

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Miscellaneous Contributions

[] Diary of The Trip to the USSR, December 8, 1989 - January 1, 1990 (Upon request to hal@dtrends.com).
[] Scientific Collaboration: SCRI, ITBA, & RAS, Nauk, Moscow, Russia, 1992.
[] Bioinformatics, Supercomputing, and Complex Genome Analysis, Human Genome News, January 1993; 4(5).
[] Tribute to Academician Bayev, Special Tribute Volume for Academician A. Bayev, Moscow, Russia, 1995. Article translated into Russian. (Article in Word [English]).
[] Biology as a Business Venture and the Rise of Bioinformatics, 1996.
[] Bioinformatics & Cheminformatics in the Drug Discovery Cycle, 1997.
[] Bioinformatics takes charge, 1997.
[] Bioinformatics, pharma and farmers, 1998.
[] Bioinformatics in pre- and post genomics eras, 1999.
[] Editorial Advisory Board, Bioinformatics: Getting results in the era of high-throughput genomics, 3/2001.
[] Human Cloning: To be or not to be?, 2001.
[] Stem Cell Research: A market for human embryos?, 2001.
[] Other Articles, 2000-2001.

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Appointments Outside D'Trends, Inc.

[] ADDA Computers, Silicon Valley, Cupertino, California (Oct 2007 - Feb 2008). Help with legal matters.
[] Secretary-General, IVY 25, Silicon Valley, California (2002 - 2006).
[] International Advisory Council, Project Management Association (DEEI-CAS), Shanghai, China (2002 - present).
[] External Advisory Council, The University of Texas at Dallas Office of the Vice President for Research and Graduate Education (2002 - present).
[] Board Member, NanoDiagnostiX, Inc. (incorporated in California), Silicon Valley, California (2002 - 2004).
[] Board Member, AbMetrix, Inc. (incorporated in California), Silicon Valley, California (2000 - 2004).
[] Board Member, GeneGo, Inc. (incorporated in Indiana), New Buffalo, Michigan (2000 - present).
[] Visiting Professor, Institute of Genetics, Chinese Academy of Sciences, Beijing, & HuaDa Genome Sequencing Center, Beijing (2000 - present).
[] Scientific Advisory Board Member, Lifesensor, Inc., Malvern, Pennsylvania (1998 - present).
[] Advisory Council and Founding Advisor, Internet Biologists/Bioscience Resource on the Internet, (
NetBio) (1997 - present).
[] Scientific reviewer, National Science Foundation (NSF), USA (1993 - present).
[] Scientific reviewer, National Cancer Institute (NCI), USA (1992 - present).
[] Consultant, National Institutes of Health (NIH), USA (1993 - present).
[] Bioinformatics Expert, Food And Agricultural Organization (FAO), United Nations (UN), (1993 - present).

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Former Students and Associates

NameTitleCareer advancement to (...) after leaving Hal's group


Donna E. Middleton Work on electrophoresis in a microgravity environment, Supported by TRDA 205, 1990-1992 (Supercomputer Computations Res. Inst.)

Orazio Whited High school student intern, 1992-1995 (University)

Vann Patacsil High school student intern, 1992-1993 (University)

Julio Arrecis MIT Chemistry Ph.D. candidate, (graduated from MIT, Boston, Massachusetts, June 1992): Dissertation Title: Quantum molecular dynamic structural calculation of bacteriorhodopsin ― alight transducing bacteria protein that functions as a proton pump (Florida Department of Natural Protection)

Stephen L. DeKorte FSU Physics Undergraduate (B.S.), Supported by DE-FG05-93ER25147, 1993-1995 (Marble Associates, Boston)

Young Park Ph.D. Candidate, FAMU/FSU Chemical Engineering, Supported by TRDA 116 and TRDA 206, Dissertation Title: Experimental and Theoretical Biological Macromolecules Separation, 1989-1993, Co-supervised by Dr. B. Locke and Dr. P. Arce, Graduated June, 1993 (Environmental Research Department, Hyundai Res. Inst., Ulsan, Korea)

Marshall Troy Carroll FSU Computer Science Undergraduate (B.S.), Supported by TRDA 113, TRDA 116 and TRDA 205, 1991-1993 (AT&T Data System, Atlanta)

Clay Garrard FSU Computer Science Undergraduate (B.S.), Supported by TRDA 113, TRDA 116 and TRDA 205, 1991-1992 (AT&T Data System, Atlanta)

James M. Lamb FAMU/FSU College of Engineering Undergraduate (B.S.), Supported by TRDA 205 (Graduated 1994, own business)

Lindsey H. Walker North Florida Christian High School, Supported by TRDA 205, 1991-1994 (private sector, Atlanta, Georgia)

Bruce Applegate undergraduate of MIT, Summer Intern, 1992 (MIT)

Eugene Chang National Science Foundation Young Scholar, Supported by NSF, 1992 (Harvard University Medical School)

Stacey L. Serafini National Science Foundation Young Scholar, Supported by NSF, co-supervised by Dr. Kenneth Johnson, 1991 (University)

Gary L. Fay National Science Foundation Young Scholar, Supported by NSF, co-supervised by Dr. Susan Ying, 1991 (California Institute of Technology)

Charles M. Bauer FSU Computer Science (M.S.), Thesis Title: A Vectorized Implementation of a Cellular Automaton for Lattice Gas Hydrodynamics, co-supervised by Dr. G. Riccardi, graduated Spring, 1990 (FSU Microcomputer Center)

Sanjay Sharma FSU Computer Science (M.S.), Thesis Title: Towards the Implementation of the Graphical Environment for Simulating 2-Dimensional Lattice Gas Models, co-supervised by Dr. G. Riccardi, graduated Summer, 1989 (National Center For Scientific Applications, University of Urbana-Champagne)

Dr. Andrew Hasenfeld (Ph.D., University of California, Berkeley), Post-doctoral fellow from Prof. Charles R. Cantor, Director, Genome Center, Lawrence Berkeley National Laboratory, Work on electrophoresis (Harvard, Boston)

Dr. Ron DeBry (Ph.D., Woods Hole Institute), work on phylogenetic trees of evolution (Biological Sciences, Florida State University)

Dr. Sergey Korolev (Ph.D., Engelhardt Institute of Molecular Biology, Moscow), Work on nucleotide acids representations using fractal (Indiana University)

Dr. Dimitriy Kuznetsov (Ph.D., Engelhardt Institute of Molecular Biology, Moscow), Work on molecular graphics of proteins (European Molecular Biol. Lab., Heidelberg, Germany)

Dr. Donald F. McMullen Work on DNA analysis using associated memory and neural network (Center for Innovative Computer Applications, Indiana University)

Eric Pepke Graphics Specialist, Work on computer graphics rendering of biological molecules (Supercomputer Computations Res. Inst., FSU, Florida)

Dr. Buks van Rensburg (Ph.D., Cambridge University, UK), Work on topologically non-trivial biological macromolecules, DNA knots (Professor of the Department of Mathematics, University of York, Canada)

Dr. Ilya Shindyalov (Ph.D., Institite of Cytology, Novosibirsk, Russia), Work on homologous sequence database compilation, integration of databases (San Diego Supercomputer Center, San Diego, California)

Dr. Victor Solovyev (Ph.D., Institute of Cytology, Novosibirsk, Russia), Work on nucleotide acids sequence and amino acid sequence representations, protein secondary structure (Amgen Inc., Thousand Oaks, California)

Gabor Varga Work on H-Tree representaions of protein sequences (Elly Lilly Pharmaceuticals, Indianapolis, Indiana)


Dr. Victor Strelets (Ph.D., Institute fo Cytology, Novosibirsk, Russia), Work on genetic data compression, splice junction (Indiana University Genome Center)

Elena Kenderova Work on electrophoresis (State University of New York, Binghamton)

2002-present (Referee)

Benson Chan MBA, University of Phoenix (Senior Vice President, Bank of America, North Carolina)

Josh Buessing MBA, University of Phoenix (General Manager, Spectra Laboratories, Inc., California)

Dr. Khor Tin Oo Ph.D., University of Malaya (Post-doctoral fellow, Rutgers University, New Jersey)

Yeoh Chin Sing High school, Malaysia (University of Edinburgh Medical School, Scotland)

Siew Choon Tee M.S., University Putra of Malaysia (University of Medicine and Dentistry of New Jersey)

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Hwa A. Lim on a bike

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BioinfoHAL on Facebook

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